By Marc Daeron,Falk Nimmerjahn
This quantity offers a cutting-edge replace on Fc Receptors (FcRs). it's divided into 5 elements. half I, Old and New FcRs, bargains with the long-sought-after FcµR and the lately found FCRL relatives and TRIM21. half II, FcR Signaling, provides a computational version of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. half III, FcR Biology, addresses significant physiological features of FcRs, their glycosylation, how they set off and control either adaptive immune responses and irritation, specifically in vivo, FcR humanized mice, and the multifaceted homes of FcRn. half IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and no matter if their FcRs make macaques reliable versions for learning HIV an infection. partly V, FcRs and healing Antibodies, the jobs of varied FcRs, together with FcγRIIB and FcαRI, within the immunotherapy of melanoma and autoimmune illnesses utilizing monoclonal antibodies and IVIg are highlighted. All 18 chapters have been written through revered specialists of their fields, providing a useful reference resource for scientists and clinicians drawn to FcRs and the way to raised grasp antibodies for healing purposes.
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Fc Receptors (Current Topics in Microbiology and Immunology) by Marc Daeron,Falk Nimmerjahn