DNA Methylation Microarrays: Experimental Design and by Sun-Chong Wang,Art Petronis PDF

By Sun-Chong Wang,Art Petronis

supplying an interface among dry-bench bioinformaticians and wet-lab biologists, DNA Methylation Microarrays: Experimental layout and Statistical Analysis offers the statistical equipment and instruments to investigate high-throughput epigenomic facts, particularly, DNA methylation microarray info. due to the fact those microarrays proportion an identical underlying ideas as gene expression microarrays, a number of the analyses within the textual content additionally practice to microarray-based gene expression and histone amendment (ChIP-on-chip) experiences.

After introducing simple records, the booklet describes wet-bench applied sciences that produce the knowledge for research and explains how one can preprocess the knowledge to take away systematic artifacts due to size imperfections. It then explores differential methylation and genomic tiling arrays. targeting exploratory facts research, the subsequent numerous chapters exhibit how cluster and community analyses can hyperlink the features and roles of unannotated DNA parts with identified ones. The ebook concludes by means of surveying the open resource software program (R and Bioconductor), public databases, and different on-line assets to be had for microarray examine.

Requiring in simple terms restricted wisdom of facts and programming, this booklet is helping readers achieve an effective knowing of the methodological foundations of DNA microarray analysis.

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DNA Methylation Microarrays: Experimental Design and Statistical Analysis (Chapman & Hall/CRC Biostatistics Series) by Sun-Chong Wang,Art Petronis


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