By George M. Rodgers
This entire quantity discusses the protease ADAMTS13, summarizing the present prestige of uncomplicated and medical study. The 9 authoritative chapters commence with a historic viewpoint through exploration of the biochemistry and structure-function relationships of ADAMTS13 in addition to its common functionality in hemostasis (cleavage of von Willebrand factor). rising examine issues for ADAMTS13 are coated, together with its strength position in angiogenesis and different elements of mobile biology. extra subject matters comprise laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and bought ADAMTS13 deficiency. A bankruptcy on similar thrombotic microangiopathic (TMA) issues examines the diversities among TMAs linked to ADAMTS13 deficiency and people no longer linked to ADAMTS13 deficiency. a last bankruptcy studies the initial info on rising features of ADAMTS13, akin to the prestige of recombinant ADAMTS13 items and their power utility.
Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and illness is an important source for medical hematologists, transfusion drugs physicians, and researchers attracted to hemostasis, vascular biology, biochemistry, and metalloproteases.
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ADAMTS13: Biology and Disease by George M. Rodgers