Download e-book for kindle: Activation-Induced Deaminase: On the Targeting Mechanism of by Andrew Franklin

By Andrew Franklin

During the process the immune reaction, antigen-activated B cells produce antibodies with elevated affinity for the antigen, a procedure known as affinity maturation. a bunch produces antibodies with successively higher affinities with repeated publicity to an identical antigen, that's the main during which so much vaccines work.
Affinity maturation depends on hypermutation, an iterative means of mutation at antibody-encoding genes, via optimistic collection of B cells expressing antibodies with elevated affinity. The mechanism of hypermutation is taken into account to be one of many final nice mysteries in molecular biology. Mutation may end up in genomic instability, so how are mutations selectively brought to antibody-encoding genes in activated B cells?
A significant step forward got here in 2000 with the invention that activation-induced deaminase (AID) is de facto required for hypermutation. This was once in 2002 via proof that relief without delay edits the DNA that encodes an antibody in an activated B cellphone. a lot has considering that been learnt in regards to the biochemistry and rules of reduction, however the mechanism wherein it truly is recruited in particular to antibody-encoding genes is still enigmatic. knowing this recruitment is clinically major simply because off-target relief task at oncogenes can result in chromosomal translocations and tumorigenesis.
This publication summarizes the study on relief within the context of its vital function within the affinity maturation of B cells.

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Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci by Andrew Franklin


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